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Tumours in historical and social context in the modern period
Hrudka, Jan ; Komárek, Stanislav (advisor) ; Tinková, Daniela (referee) ; Stingl, Josef (referee)
Univerzita Karlova v Praze Přírodovědecká fakulta Studijní program: Filosofie a dějiny přírodních věd MUDr. Jan Hrudka Nádory v dějinném a kulturním kontextu v novověku Tumours in historical and social context in the modern period Disertační práce Školitel / Supervisor: Prof. RNDr. Stanislav Komárek, Dr. Praha, 2017 SUMMARY: The PhD thesis called Tumours in historical and social context in the modern period is an attempt to describe a change of medical thinking in modern period; science and medicine turns from antique humoral pathology, explaining all diseases as an imbalance of the four body humours, to pathological anatomy and experimental physiology. In the point of view of pathological anatomy, the viscera of diseased person are no more "screen" or "mirror" of the disease, but it becomes directly the "stage" or "theatre" of the acting disease. This shift in the thought may be labelled as movement from humoralism to localism or ontologism; the disease isn't just abnormal amount of some natural juice any more, but becomes new original entity. This change undergoes the understanding of tumours and cancerous disease as well. Instead of antique understanding tumours as precipitates of black bile, the cell theory occurs in the 19th century. This theory explains tumours as a mass of cells undergoing excessive...
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Iron metabolism in cancer cells
Beranová, Lea Marie ; Truksa, Jaroslav (advisor) ; Čermák, Vladimír (referee)
1Abstract: Cancer is one of the major causes of death in the present world. As the research of this disease has progressed, the attention of some scientists has been focused on a metabolism of iron and how it can be used to fight these rapidly proliferating invasive cells and stop their spreading. This work should serve as a brief review of iron metabolic processes from the iron absorption from dietary resources and recycled cell iron, to its usage in heme- or Fe/S clusters-proteins and storage in a form of ferritin, while highlighting the points that differ in cancer cells. It also gives a modest overview on the regulatory pathways of iron uptake and use, and mentions iron metabolism disorders such as iron-depletion and overload. Simultaneously it is denoting possible differences that could be targeted in tumor treatment, and, at least but not last, the perspectives and future work that could bring a new methods and approaches to this matter. Keywords: iron metabolism, iron, cancer, hepcidin
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Tumours in historical and social context in the modern period
Hrudka, Jan ; Komárek, Stanislav (advisor) ; Tinková, Daniela (referee) ; Stingl, Josef (referee)
Univerzita Karlova v Praze Přírodovědecká fakulta Studijní program: Filosofie a dějiny přírodních věd MUDr. Jan Hrudka Nádory v dějinném a kulturním kontextu v novověku Tumours in historical and social context in the modern period Disertační práce Školitel / Supervisor: Prof. RNDr. Stanislav Komárek, Dr. Praha, 2017 SUMMARY: The PhD thesis called Tumours in historical and social context in the modern period is an attempt to describe a change of medical thinking in modern period; science and medicine turns from antique humoral pathology, explaining all diseases as an imbalance of the four body humours, to pathological anatomy and experimental physiology. In the point of view of pathological anatomy, the viscera of diseased person are no more "screen" or "mirror" of the disease, but it becomes directly the "stage" or "theatre" of the acting disease. This shift in the thought may be labelled as movement from humoralism to localism or ontologism; the disease isn't just abnormal amount of some natural juice any more, but becomes new original entity. This change undergoes the understanding of tumours and cancerous disease as well. Instead of antique understanding tumours as precipitates of black bile, the cell theory occurs in the 19th century. This theory explains tumours as a mass of cells undergoing excessive...
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Iron metabolism in cancer cells
Beranová, Lea Marie ; Truksa, Jaroslav (advisor) ; Čermák, Vladimír (referee)
1Abstract: Cancer is one of the major causes of death in the present world. As the research of this disease has progressed, the attention of some scientists has been focused on a metabolism of iron and how it can be used to fight these rapidly proliferating invasive cells and stop their spreading. This work should serve as a brief review of iron metabolic processes from the iron absorption from dietary resources and recycled cell iron, to its usage in heme- or Fe/S clusters-proteins and storage in a form of ferritin, while highlighting the points that differ in cancer cells. It also gives a modest overview on the regulatory pathways of iron uptake and use, and mentions iron metabolism disorders such as iron-depletion and overload. Simultaneously it is denoting possible differences that could be targeted in tumor treatment, and, at least but not last, the perspectives and future work that could bring a new methods and approaches to this matter. Keywords: iron metabolism, iron, cancer, hepcidin
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The incidence of secondary tumors after irradiation for carcinoma of the uterine body.
TESAŘOVÁ, Lenka
ANNOTATION: Malignant tumours of the corpus uteri are among the most frequently occurring gynaecological conditions. Endometrial carcinoma represents 96{--}98% of all malignities in corpus uteri tumours. Occurrence of this condition in the Czech Republic: in 2007, 1726 new cases were diagnosed, which represents approximately 32.7 cases per 100 thousand women. Almost 75% of the patients are diagnosed in the first stage of the disease. The age median of the patients with a diagnosed tumour of the corpus uteri is 61 years. Secondary tumours occur from mutations several years after radiation exposure. They result from the previously administered chemotherapy or radiotherapy leading to the damage to the genetic information in the cells. The mutation affects the cells that relate to the formation of secondary malignities. The aim of my bachelor{\crq}s thesis is to find out about the occurrence of the secondary tumour with cancer of the corpus uteri among those who received radiotherapy at the Department of Oncology at Hospital České Budějovice between years 1978-98. In my thesis I evaluated the number of secondary tumours, time of their occurrence, relative risks, and whether they are located within or outside the irradiated field. The thesis is divided in two main parts: a theoretical part where I deal with the tumour itself, radiotherapy, and radiobiology; and a practical part that presents concrete statistics issuing from the aim of my work. I found out that secondary tumours occur more frequently outside the irradiated area. The results suggest that secondary tumours may occur from the effects of the ionising radiation on the organism. This probably relates to the fact that there are lethal changes within the area exposed to radiation whereas in areas receiving low doses of radiation the cells are damaged, which may, after many years, lead to the occurrence of secondary tumours. I chose this topic also to emphasise the fact that besides the curing of the primary tumour one also needs to pay attention to dispensing a routine that may aid the early detection of further tumours
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